Duodenal Ulcer
A duodenal ulcer is an open sore that forms on the lining of the duodenum, the first section of the small intestine just below the stomach. The burning or gnawing pain it causes typically strikes between meals and at night, and often eases temporarily after eating. Most cases trace back to infection with Helicobacter pylori bacteria or long-term use of anti-inflammatory painkillers (NSAIDs). H. H. pylori infection is a common cause of duodenal ulcers and related digestive complaints.
Key points
- Infection with Helicobacter pylori or prolonged NSAID use are the most frequent causes of this open sore in the duodenum.
- Pain often appears between meals and overnight, then eases for a while once food is eaten.
- Proton pump inhibitors such as rabeprazole cut acid secretion sharply, letting misoprostol protect the lining when NSAIDs continue.
Reducing acid and protecting the gut lining
Healing a duodenal ulcer requires lowering the acid load inside the stomach and, where relevant, shielding the gut wall from further damage. Proton pump inhibitors do both jobs well: rabeprazole is a PPI that cuts acid secretion sharply, allowing the ulcerated tissue to repair. When an ulcer has developed because of NSAID use, misoprostol can be added to reinforce the mucosal lining and reduce the risk of further injury. Both medicines sit within the broader digestive health catalogue.
Seek medical attention promptly if you notice black or tarry stools, vomit that looks like coffee grounds, or sudden severe abdominal pain. These can signal bleeding and need same-day assessment.