Roflumilast
Roflumilast is a medication commonly known by the brand name Daxas. It is a targeted treatment designed to address inflammation associated with Chronic Obstructive Pulmonary Disease. Daliresp is available to support individuals managing these respiratory symptoms. This preparation is a primary option for people seeking sustained relief from chronic airway issues.
Key points
- Intended for long-term maintenance rather than as a rescue treatment during a sudden breathing attack.
- Works by raising cyclic AMP levels inside inflammatory cells, which reduces inflammation in the lungs over time.
- A history of depression or significant liver problems may make this medicine less suitable, and unintended weight loss should be monitored early in treatment.
- Reduces how often flare-ups occur in chronic obstructive pulmonary disease by targeting the airway inflammation behind them.
What is Roflumilast?
Roflumilast is a selective phosphodiesterase-4 (PDE4) inhibitor used to manage chronic inflammatory conditions in the airways. By targeting the underlying inflammation, it serves as a long-term maintenance treatment rather than a rescue medication for sudden episodes. It provides a distinct approach to therapy when other standard therapies are insufficient.
What Roflumilast is used for
This medication is primarily indicated for the management of Chronic Obstructive Pulmonary Disease. It works to reduce the frequency of exacerbations or flare-ups, helping stabilise breathing for individuals living with long-term obstructive airway issues. It is not intended to treat acute asthma attacks or immediate breathing difficulties.
How does Roflumilast work?
Roflumilast works by blocking an enzyme called PDE4, which is found in inflammatory cells. Inhibiting this enzyme increases levels of cyclic AMP within these cells, which effectively puts the brakes on the inflammatory process in your lungs. Reducing this cellular inflammation helps improve overall airflow and limits the tissue damage that leads to worsening symptoms over time.
Roflumilast brands and forms
Patients have access to established brand formulations such as Daxas and Daliresp, which are formulated as specific strengths for daily oral use. These options fall under the broader category of Respiratory Health treatments. Our current catalogue presents the film-coated tablet formulation designed for consistent absorption. Choosing between brands often depends on regional availability and specific doctor recommendations.
Safety overview for Roflumilast
What to check before using this medicine
Ensure that you have discussed your complete medical history with your healthcare provider, particularly if you have a history of depression, liver impairment, or underweight conditions. Roflumilast may not be suitable for people with specific pre-existing mental health concerns or severe liver issues.
Possible reactions and tolerability
Some individuals may experience common effects such as nausea, diarrhoea, or changes in sleep patterns when starting the medication. These digestive symptoms often subside as your body adjusts to the therapy over the first few weeks. Monitor your weight, as unintentional weight loss can sometimes occur during initial treatment phases.
Interactions and health factors
Certain medications, including those used for epilepsy or strong anti-infective drugs, may interfere with how your body clears Roflumilast. Always declare all concurrent supplements and medications to your doctor. Product labelling and verified clinical sources remain the correct references for specific contraindications, interactions and reactions.
Further reading
What is roflumilast used for?
Roflumilast is used to manage chronic obstructive pulmonary disease. It reduces how often flare-ups occur and helps stabilise breathing in people with long-term obstructive airway issues. It is not meant to treat acute asthma attacks or immediate breathing difficulties.
How does roflumilast work?
Roflumilast blocks an enzyme called PDE4 found in inflammatory cells. This raises cyclic AMP levels inside those cells and puts the brakes on the inflammatory process in your lungs. Lower inflammation helps improve overall airflow and limits the tissue damage that worsens symptoms over time.
How long does roflumilast take to work?
Roflumilast usually takes 2 to 4 weeks to show its full effect. It is a long-term maintenance treatment, not a rescue medicine for a sudden breathing attack.
What are the side effects of roflumilast?
Common effects include diarrhoea, nausea, weight loss and abdominal pain, and some people notice headache, insomnia or anxiety. These digestive symptoms often subside as your body adjusts over the first few weeks, but you should monitor your weight. Serious reactions such as severe depression or suicidal ideation need immediate medical attention, so speak to your doctor or pharmacist if anything worries you.
Who should not take roflumilast?
Roflumilast may not be suitable if you have moderate to severe hepatic impairment, severe immunological diseases or severe acute infectious diseases. A history of depression or significant liver problems may also make it less suitable. It should not be used if you have a hypersensitivity to it, so discuss your complete medical history with your healthcare provider first.
Can roflumilast be taken with other medicines?
Certain medicines, including those used for epilepsy or strong anti-infective drugs, may interfere with how your body clears roflumilast. Rifampicin, phenobarbital, carbamazepine and phenytoin are among those that interact. Always declare all concurrent supplements and medications to your doctor or pharmacist.
What roflumilast products are available?
Products containing roflumilast include Daliresp. Compare forms, strengths and packs in the listings above.
What are other names for roflumilast?
Besides the products listed here, roflumilast is sold under brand names such as Daxas. Names differ from country to country, so the active ingredient is the surest way to compare.
Is roflumilast available over the counter in Thailand?
Yes. In Thailand roflumilast is sold by pharmacists without a prescription, and Yasabai does not ask for one either. We are an online store, not a dispensing pharmacy; we arrange your order and delivery on your behalf.
Ordering without a prescription →Do you deliver roflumilast to Thailand?
Yes. Our pharmacy partners ship from India to Thailand and across Asia in discreet packaging. Standard Airmail takes up to 3 weeks; Express Tracked Courier takes up to 1 week.
How ordering works →