Sinemet CR
Sinemet CR is carbidopa with levodopa 25/100mg in a modified-release tablet for Parkinson's disease, spreading the dose across a longer period.
- Condition
- Parkinson's Disease
- Alternative names
- Sinemet; Caramet; Duodopa
- Therapeutic class
- Dopamine Precursor / Dopa Decarboxylase Inhibitor
- Pharmacological class
- Dopaminergic Agent
- Minor side effects
- nausea; dizziness; dry mouth
- Moderate side effects
- involuntary movements; confusion; orthostatic hypotension
- Dosage forms
- Modified-release tablet
- Administration route
- Oral use
- Manufacturer
- MSD
- Onset time
- 30–90 minutes
- Duration
- 4–6 hours
- Storage instructions
- Store below 25°C, keep container closed.
- Drug interactions
- iron supplements; antipsychotics
- Age restrictions
- Not recommended for children.
- Pregnancy and breastfeeding
- Pregnancy: Consult healthcare professional. Breastfeeding: Avoid administration.
Contraindications
hypersensitivity to components; narrow-angle glaucoma; concurrent use of non-selective maois
Precautions and warnings
may cause sudden sleep onset; monitor for impulse control disorders; avoid rapid discontinuation
Serious side effects
hallucinations, requires immediate medical attention; malignant syndrome, requires immediate medical attention
Patient summary
Sinemet CR is carbidopa with levodopa 25/100mg in a modified-release tablet for Parkinson's disease, spreading the dose across a longer period.
Mechanism of action
Sinemet CR combines levodopa, which crosses the blood-brain barrier to be converted into dopamine, and carbidopa, which prevents periphery metabolism of levodopa. This allows more active substance to reach the brain to improve movement control.
Sinemet CR combines carbidopa and levodopa for the management of Parkinson’s Disease. This therapeutic formula is also sold under brand names including Sinemet, Caramet and Duodopa. It is supplied as a tablet in a 25/100mg strength.
Buying Sinemet CR
Generic carbidopa and levodopa, much of it made in India, provides a far more affordable option compared to the original brand, helping expats and residents secure consistent access to their regular maintenance medication.
What exactly is supplied when I order Sinemet CR?
A branded generic or generic containing carbidopa and levodopa, at the strength you choose. Yasabai lists the medicine as Sinemet CR; the exact brand and manufacturer depend on stock. The combination is a dopamine precursor / dopa decarboxylase inhibitor, used for Parkinson's disease.
How is Sinemet CR priced?
It depends on the strength and pack. Sinemet CR comes in a 25/100mg strength, in packs of 30 to 360 tablets, and the price per tablet for every option is shown above, in US dollars or the currency you choose. Larger packs cost less per tablet. Paying with Bitcoin or Ethereum gives you an extra 10% off.
What are other brand names for carbidopa and levodopa?
Other brands of carbidopa and levodopa include Caramet and Duodopa. On Yasabai the same ingredients come as Sinemet.
What does Sinemet CR treat?
Sinemet CR contains carbidopa and levodopa, used for Parkinson's disease. Sinemet CR combines levodopa, which crosses the blood-brain barrier to be converted into dopamine, and carbidopa, which prevents periphery metabolism of levodopa.
When does Sinemet CR start working?
Carbidopa and levodopa usually start to work within 30 to 90 minutes, and their effect lasts about 4 to 6 hours. It varies from person to person.
What are the side effects of Sinemet CR?
The common side effects of carbidopa and levodopa are nausea, dizziness and dry mouth. Less common ones include involuntary movements, confusion and orthostatic hypotension. Serious but less common side effects include hallucinations and malignant syndrome, which need urgent medical attention.
Can I take Sinemet CR with other medicines?
Carbidopa and levodopa can interact with iron supplements and antipsychotics. Tell your doctor or pharmacist about every medicine you take before you start Sinemet CR.
Can I buy Sinemet CR over the counter in Thailand?
Yes. In Thailand carbidopa and levodopa are sold by pharmacists without a prescription, and Yasabai does not ask for one either. We are an online store, not a dispensing pharmacy; we arrange your order and delivery on your behalf.
Ordering without a prescription →Do you deliver Sinemet CR to Thailand?
Yes. Our pharmacy partners ship from India to Thailand and across Asia in discreet packaging. Standard Airmail takes up to 3 weeks; Express Tracked Courier takes up to 1 week.
How ordering works →What you will receive
Sinemet CR is the name this medicine is listed under. What you receive is a branded generic or generic with the same active ingredient (Carbidopa / Levodopa) at the same dose.
- We supply branded generics and generics only, mostly recognised Indian branded generics from vetted manufacturers, not originator brand packs.
- The exact brand and manufacturer depend on what is in stock at the dispatching warehouse.