Sinemet
Carbidopa with levodopa in three tablet strengths, plain and prolonged-release, used in the management of Parkinson's disease. A precursor with its protector.
- Condition
- Parkinson's Disease
- Alternative names
- Sinemet CR
- Therapeutic class
- Dopaminergic Agent
- Pharmacological class
- Decarboxylase Inhibitor/Dopamine Precursor
- Minor side effects
- dyskinesia; nausea; dizziness; dry mouth
- Moderate side effects
- orthostatic hypotension; confusion; insomnia
- Dosage forms
- Tablet; Prolonged-release tablet
- Administration route
- Oral use
- Originator
- MSD
- Onset time
- 30–60 minutes
- Duration
- 3–6 hours
- Storage instructions
- Store below 25°C in original packaging.
- Drug interactions
- antipsychotics; iron supplements; antihypertensives
- Age restrictions
- Not for paediatric use.
- Pregnancy and breastfeeding
- Pregnancy: Not recommended. Breastfeeding: Not recommended.
Contraindications
hypersensitivity to ingredients; narrow-angle glaucoma; concurrent use of non-selective mao inhibitors
Precautions and warnings
may cause sudden sleep onset; monitor for impulse control disorders; periodic haematological monitoring advised
Serious side effects
hallucinations, requires immediate medical attention; neuroleptic malignant syndrome, requires immediate medical attention
Patient summary
Carbidopa with levodopa in three tablet strengths, plain and prolonged-release, used in the management of Parkinson's disease. A precursor with its protector.
Mechanism of action
Levodopa is a precursor to dopamine that crosses the blood-brain barrier. Carbidopa prevents peripheral metabolism of levodopa, increasing the amount available for dopamine conversion in the brain.
Sinemet is the standard treatment for Parkinson’s Disease, containing the active ingredients Carbidopa and Levodopa. The same components are also marketed under the brand Sinemet CR. These tablets are used to manage symptoms and are available in strengths of 10/100, 25/100 and 25/250mg.
Buying Sinemet online
Generic Carbidopa and Levodopa are often available as a more affordable solution than the original MSD brand, making it easier for those living away from local medical suppliers to coordinate delivery across Thailand and the rest of Asia.
Will I receive the original Sinemet?
No. Sinemet is the originator brand name, made by MSD, and Yasabai uses it to identify the medicine: you receive a generic with the same active ingredients (carbidopa and levodopa) at the same doses, mostly a recognised Indian branded generic. The exact brand depends on stock.
What is the price of Sinemet?
It depends on the strength and pack. Sinemet comes in 10/100, 25/100 and 25/250mg strengths, in packs of 30 to 360 tablets, and the price per tablet for every option is shown above, in US dollars or the currency you choose. Larger packs cost less per tablet. Paying with Bitcoin or Ethereum gives you an extra 10% off.
What other names is Sinemet sold under?
On Yasabai the same ingredients come as Sinemet CR.
What is Sinemet used for?
Sinemet contains carbidopa and levodopa, used for Parkinson's disease. Levodopa is a precursor to dopamine that crosses the blood-brain barrier.
How long does Sinemet take to work?
Carbidopa and levodopa usually start to work within 30 to 60 minutes, and their effect lasts about 3 to 6 hours. It varies from person to person.
What side effects can Sinemet cause?
The common side effects of carbidopa and levodopa are dyskinesia, nausea, dizziness and dry mouth. Less common ones include orthostatic hypotension, confusion and insomnia. Serious but less common side effects include hallucinations and neuroleptic malignant syndrome, which need urgent medical attention.
Can I take Sinemet with other medicines?
Carbidopa and levodopa can interact with antipsychotics, iron supplements and antihypertensives. Tell your doctor or pharmacist about every medicine you take before you start Sinemet.
Can I buy Sinemet over the counter in Thailand?
Yes. In Thailand carbidopa and levodopa are sold by pharmacists without a prescription, and Yasabai does not ask for one either. We are an online store, not a dispensing pharmacy; we arrange your order and delivery on your behalf.
Ordering without a prescription →Can I order Sinemet online for delivery in Thailand?
Yes. Our pharmacy partners ship from India to Thailand and across Asia in discreet packaging. Standard Airmail takes up to 3 weeks; Express Tracked Courier takes up to 1 week.
How ordering works →What you will receive
Sinemet is the originator brand name, made by MSD. We use it here to identify the medicine only; we are not affiliated with MSD and do not ship the original Sinemet.
- You receive a generic equivalent: the same active ingredient (Carbidopa / Levodopa) at the same dose, mostly recognised Indian branded generics from vetted manufacturers.
- The exact brand supplied depends on what is in stock at the dispatching warehouse.
- A regulated generic matches the original ingredient for ingredient by legal standard.